Functional Roles of Urea Synthesis in Vertebrates

@article{Atkinson1992FunctionalRO,
  title={Functional Roles of Urea Synthesis in Vertebrates},
  author={Daniel E. Atkinson},
  journal={Physiological Zoology},
  year={1992},
  volume={65},
  pages={243 - 267}
}
The urea cycle occurs widely in vertebrates, serving different functions in different lineages. In elasmobranchs, where it contributes to osmolar balance, the product urea itself is functionally useful. In other vertebrates the synthesis of urea serves functions other than provision of urea. In air-breathing fish, amphibians, and mammals ureagenesis generates protons that contribute to pH homeostasis by titration of metabolically produced bicarbonate, and in ruminants this function is… Expand
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