Functional Reintegration of Sensory Neurons and Transitional Dendritic Reduction of Mitral/Tufted Cells during Injury-Induced Recovery of the Larval Xenopus Olfactory Circuit

@article{Hawkins2017FunctionalRO,
  title={Functional Reintegration of Sensory Neurons and Transitional Dendritic Reduction of Mitral/Tufted Cells during Injury-Induced Recovery of the Larval Xenopus Olfactory Circuit},
  author={Sara Joy Hawkins and Lukas Weiss and Thomas Offner and Katarina Dittrich and Thomas Hassenkl{\"o}ver and Ivan Manzini},
  journal={Frontiers in Cellular Neuroscience},
  year={2017},
  volume={11}
}
Understanding the mechanisms involved in maintaining lifelong neurogenesis has a clear biological and clinical interest. In the present study, we performed olfactory nerve transection on larval Xenopus to induce severe damage to the olfactory circuitry. We surveyed the timing of the degeneration, subsequent rewiring and functional regeneration of the olfactory system following injury. A range of structural labeling techniques and functional calcium imaging were performed on both tissue slices… 

Figures from this paper

Structural and Functional Plasticity in the Regenerating Olfactory System of the Migratory Locust
TLDR
This review introduces the olfactory pathway of a particular insect as a convenient model to visualize neural regeneration at an anatomical level and study functional recovery at an electrophysiological level, and concludes that axonal regeneration in the locust Olfactory system appears to be possible, precise, and fast.
Purinergic signalling selectively modulates maintenance but not repair neurogenesis in the zebrafish olfactory epithelium
TLDR
It is hypothesize that purine compounds released from dying OSNs modulate GBC progenitor cell cycling in a dose‐dependent manner that is proportional to the number of dyingOSNs and, thereby, ensures a constant pool of sensory neurons over time.
Wiring and information processing in the olfactory bulb of larval Xenopus laevis
TLDR
Overall, this work suggests, that the lateral olfactory subsystem incorporates several different wiring logics and resembles a rodent ‘accessory Olfactory system-like’ subsystem that is still undergoing developmental processes.
Olfaction across the water–air interface in anuran amphibians
TLDR
The structure of the peripheral Olfactory organ, the olfactory bulb, and higher olf factory centers are described on a tissue, cellular, and molecular levels.
Olfactory neurogenesis during tissue maintenance and repair
Wahrend der Metamorphose durchlauft der Krallenfrosch Xenopus laevis eine grundlegende Transformation von einer vollstandig aquatischen Larve zu einem sekundar aquatischen Frosch. Diese umfangreiche

References

SHOWING 1-10 OF 79 REFERENCES
Neuronal degeneration and regeneration induced by axotomy in the olfactory epithelium of Xenopus laevis
TLDR
It is found that axotomy induces specific‐ neuronal death through apoptosis between 24 and 48h post‐injury and a sequential analysis of the neurodegenerative and subsequent regenerative processes in the OE following axotomy is provided.
Contribution of olfactory neural stem cells to tissue maintenance and regeneration
TLDR
F Fate-mapping analysis after olfactory neuroepithelium lesioning shows that mouse horizontal basal cells (HBCs) are competent to regenerate both neuronal and non-neuronal olfFactory neuroepIthelium lineages, which support a new model of adult neurogenesis in which distinct cell populations mediate normal neuronal turnover and neuronal replacement upon traumatic injury.
Neural regeneration and the peripheral olfactory system
TLDR
Cell renewal in the epithelium is directed to replace neurons when they die in normal animals and does so at an accelerated pace after damage to the olfactory nerve, and multiple growth factors are likely to be central in regulating choice points in epitheliopoiesis.
Neonatal focal denervation of the rat olfactory bulb alters cell structure and survival: a Golgi, Nissl and confocal study.
The quantitative relationship between olfactory axons and mitral/tufted cells in developing Xenopus with partially deafferented olfactory bulbs.
TLDR
Olfactory-afferent innervation was critical for differentiation of the Olfactory bulb, and decreasing the number of olfactory axons resulted in a reduction in the numberof output neurons of the olfFactory bulb.
Odor Memory Stability after Reinnervation of the Olfactory Bulb
TLDR
The results show that 45 days after methimazole-induced lesion, axonal projections to the bulb of M72 and I7 populations are largely reestablished and regenerated glomeruli are re-formed within the same areas as those of control, unexposed mice.
Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis.
The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo
TLDR
This work describes a procedure for in vivo labeling of sensory neurons and subsequent visualization of axons in the olfactory system of larvae of the amphibian Xenopus laevis and adopts the electroporation technique, which represents a unique opportunity to monitor axonal wiring and guidance.
A lifetime of neurogenesis in the olfactory system
TLDR
The effect of age on the structural and functional significance of neurogenesis in the vomeronasal and olfactory epithelia, from juvenile to advanced adult ages, in several common model systems is discussed.
...
1
2
3
4
5
...