Functional Profiling Discovers the Dieldrin Organochlorinated Pesticide Affects Leucine Availability in Yeast

@inproceedings{Gaytn2013FunctionalPD,
  title={Functional Profiling Discovers the Dieldrin Organochlorinated Pesticide Affects Leucine Availability in Yeast},
  author={Brandon D. Gayt{\'a}n and Alexander V. Loguinov and Stephen R. Lantz and Jan-Michael Lerot and Nancy D. Denslow and Christopher D. Vulpe},
  booktitle={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2013}
}
Exposure to organochlorinated pesticides such as dieldrin has been linked to Parkinson's and Alzheimer's diseases, endocrine disruption, and cancer, but the cellular and molecular mechanisms of toxicity behind these effects remain largely unknown. Here we demonstrate, using a functional genomics approach in the model eukaryote Saccharomyces cerevisiae, that dieldrin alters leucine availability. This model is supported by multiple lines of congruent evidence: (1) mutants defective in amino acid… CONTINUE READING

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