Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas.

@article{Heaney2002FunctionalPR,
  title={Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas.},
  author={Anthony Patrick Heaney and Manory Fernando and William H. Yong and Shlomo Melmed},
  journal={Nature medicine},
  year={2002},
  volume={8 11},
  pages={1281-7}
}
Adrenocorticotrophic hormone (ACTH)-secreting pituitary tumors are associated with high morbidity due to excess glucocorticoid production. No suitable drug therapies are currently available, and surgical excision is not invariably curative. Here we demonstrate immunoreactive expression of the nuclear hormone receptor peroxisome proliferator-activated receptor-gamma (PPAR-gamma) exclusively in normal ACTH-secreting human anterior pituitary cells: PPAR-gamma was abundantly expressed in all of six… CONTINUE READING
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