Functional PDF Signaling in the Drosophila Circadian Neural Circuit Is Gated by Ral A-Dependent Modulation

@article{Klose2016FunctionalPS,
  title={Functional PDF Signaling in the Drosophila Circadian Neural Circuit Is Gated by Ral A-Dependent Modulation},
  author={Markus Klose and Laura B. Duvall and Weihua Li and Xitong Liang and Chi Ren and Joe Henry Steinbach and Paul H Taghert},
  journal={Neuron},
  year={2016},
  volume={90},
  pages={781-794}
}
The neuropeptide PDF promotes the normal sequencing of circadian behavioral rhythms in Drosophila, but its signaling mechanisms are not well understood. We report daily rhythmicity in responsiveness to PDF in critical pacemakers called small LNvs. There is a daily change in potency, as great as 10-fold higher, around dawn. The rhythm persists in constant darkness and does not require endogenous ligand (PDF) signaling or rhythmic receptor gene transcription. Furthermore, rhythmic responsiveness… CONTINUE READING
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