Functional Organization of the S. cerevisiae Phosphorylation Network

Abstract

Reversible protein phosphorylation is a signaling mechanism involved in all cellular processes. To create a systems view of the signaling apparatus in budding yeast, we generated an epistatic miniarray profile (E-MAP) comprised of 100,000 pairwise, quantitative genetic interactions, including virtually all protein and small-molecule kinases and phosphatases… (More)
DOI: 10.1016/j.cell.2008.12.039

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