Functional Oocytes Derived from Granulosa Cells.

@article{Tian2019FunctionalOD,
  title={Functional Oocytes Derived from Granulosa Cells.},
  author={Chenglei Tian and Linlin Liu and Xiaoying Ye and Haifeng Fu and Xiaoyan Sheng and Lingling Wang and Huasong Wang and Dai Heng and Lin Liu},
  journal={Cell reports},
  year={2019},
  volume={29 13},
  pages={
          4256-4267.e9
        }
}
Induction of meiosis by embryonic gonadal somatic cells differentiated from pluripotent stem cells
  • Haiying Wang, Linlin Liu, +11 authors Lin Liu
  • Medicine
    Stem cell research & therapy
  • 2021
Background Depletion of oocytes leads to ovarian aging-associated infertility, endocrine disruption and related diseases. Excitingly, unlimited oocytes can be generated by differentiation of
Advances in Female Germ Cell Induction from Pluripotent Stem Cells
TLDR
Germ cell differentiation from pluripotent stem cells in vitro can simulate early embryonic development of female germ cells and clarify unresolved issues during the development process and could potentially provide promising applications for female fertility preservation after proper in vitro differentiation.
Generation of developmentally competent oocytes and fertile mice from parthenogenetic embryonic stem cells.
TLDR
It is shown that an unlimited number of oocytes can be derived from pESCs and produce healthy offspring, and amplification of germ cells through parthenogenesis faithfully maintains maternal imprinting, offering a promising route for deriving functional oocytes and having potential in rebuilding ovarian endocrine function.
Mtor inhibition by INK128 extends functions of the ovary reconstituted from germline stem cells in aging and premature aging mice
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Germline stem cell transplantation in combination with mTOR inhibition by INK128 improves and extends the reconstituted ovarian and endocrine functions in reproductive aging and premature aging mice.
Human Granulosa Cells—Stemness Properties, Molecular Cross-Talk and Follicular Angiogenesis
TLDR
It is important to carefully consider GCs as ovarian stem cells in terms of the cellular features and molecular pathways involved in their development and interactions as well as outline their possible application in translational medicine.
Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility
TLDR
The clinical application of MSCs holds great promise for the treatment of infertility or ovarian insufficiency, and to improve reproductive health for a significant number of women worldwide.
Transcriptome Profiling of the Ovarian Cells at the Single-Cell Resolution in Adult Asian Seabass
TLDR
This study analyzed the molecular signature of several distinct cell populations of Asian seabass adult ovaries through scRNA-seq and identified five cell types and successfully validated some specific genes of germ cells and granulosa cells, and found some key pathways involved in ovarian development that may concert germline-somatic interactions.
Procyanidin B2 Improves Oocyte Maturation and Subsequent Development in Type 1 Diabetic Mice by Promoting Mitochondrial Function
TLDR
It is uncovered that PB2 can improve the level of crH4K5, which provides a new strategy to combat the decline in oocyte quality of diabetic mice and is the first to reveal a role for PB2 in promoting the viability of oocytes by regulating the mitochondrial function.
MiR-214-3p Promotes Proliferation and Inhibits Estradiol Synthesis In Porcine Granulosa Cells
Background: Granulosa cells (GCs) proliferation and estradiol synthesis significantly affect follicular development. The miR-214-3p expression in the ovarian tissues of high-yielding sows is higher
Female Germ Cell Development, Functioning and Associated Adversities under Unfavorable Circumstances
TLDR
Various aspects of gametogenesis especially female gametes and relevant factors causing functional impairment have been thoroughly discussed.
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