Functional Oocytes Derived from Granulosa Cells.

  title={Functional Oocytes Derived from Granulosa Cells.},
  author={Chenglei Tian and Linlin Liu and Xiaoying Ye and Haifeng Fu and Xiaoyan Sheng and L. Wang and Huasong Wang and Dai Heng and L. Liu},
  journal={Cell reports},
  volume={29 13},
  • Chenglei Tian, Linlin Liu, +6 authors L. Liu
  • Published 2019
  • Biology, Medicine
  • Cell reports
  • The generation of genomically stable and functional oocytes has great potential for preserving fertility and restoring ovarian function. It remains elusive whether functional oocytes can be generated from adult female somatic cells through reprogramming to germline-competent pluripotent stem cells (gPSCs) by chemical treatment alone. Here, we show that somatic granulosa cells isolated from adult mouse ovaries can be robustly induced to generate gPSCs by a purely chemical approach, with… CONTINUE READING
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