Functional NOS 1 in the rat mesenteric arterial bed.

  title={Functional NOS 1 in the rat mesenteric arterial bed.},
  author={J. Charlie Sullivan and Ararat D Giulumian and David M Pollock and Leslie C Fuchs and Jennifer S. Pollock},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={283 2},
Previously we have demonstrated functional nitric oxide synthase (NOS) 1 in large arteries. Because resistance arteries largely determine blood pressure, this study examined whether functional NOS 1 also exists in resistance arteries. Phenylephrine (PE) contraction was measured in the absence and presence of the NOS 1 inhibitor N(5)-(1-imino-3-butenyl)-L-ornithine (VNIO) in isolated mesenteric resistance arteries (endothelium intact and denuded) from Sprague-Dawley rats. For NOS 1 activity and… CONTINUE READING
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