Functional Motor Recovery from Motoneuron Axotomy Is Compromised in Mice with Defective Corticospinal Projections

@inproceedings{Ding2014FunctionalMR,
  title={Functional Motor Recovery from Motoneuron Axotomy Is Compromised in Mice with Defective Corticospinal Projections},
  author={Yuetong Ding and Yibo Qu and Jia Xi Feng and Meizhi Wang and Qi Han and Kwok-fai So and Wutian Wu and Libing Zhou},
  booktitle={PloS one},
  year={2014}
}
Brachial plexus injury (BPI) and experimental spinal root avulsion result in loss of motor function in the affected segments. After root avulsion, significant motoneuron function is restored by re-implantation of the avulsed root. How much this functional recovery depends on corticospinal inputs is not known. Here, we studied that question using Celsr3|Emx1 mice, in which the corticospinal tract (CST) is genetically absent. In adult mice, we tore off right C5-C7 motor and sensory roots and re… CONTINUE READING
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