Functional Modulation of ES-Derived Hepatocyte Lineage Cells via Substrate Compliance Alteration

@article{Li2008FunctionalMO,
  title={Functional Modulation of ES-Derived Hepatocyte Lineage Cells via Substrate Compliance Alteration},
  author={Lulu Li and N. Sharma and Uday Chippada and Xue Jiang and R. Schloss and M. Yarmush and N. Langrana},
  journal={Annals of Biomedical Engineering},
  year={2008},
  volume={36},
  pages={865-876}
}
Pluripotent embryonic stem cells represent a promising renewable cell source to generate a variety of differentiated cell types including hepatocyte lineage cells, and may ultimately be incorporated into extracorporeal bioartificial liver devices and cell replacement therapies. Recently, we and others have utilized sodium butyrate to directly differentiate hepatocyte-like cells from murine embryonic stem cells cultured in a monolayer configuration. However, to incorporate stem cell technology… Expand
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