Functional Metabolomics Reveals Novel Active Products in the DHA Metabolome

@inproceedings{Shinohara2012FunctionalMR,
  title={Functional Metabolomics Reveals Novel Active Products in the DHA Metabolome},
  author={Masakazu Shinohara and Valbona Mirakaj and Charles Nicholas Serhan},
  booktitle={Front. Immun.},
  year={2012}
}
Endogenous mechanisms for successful resolution of an acute inflammatory response and the local return to homeostasis are of interest because excessive inflammation underlies many human diseases. In this review, we provide an update and overview of functional metabolomics that identified a new bioactive metabolome of docosahexaenoic acid (DHA). Systematic studies revealed that DHA was converted to DHEA-derived novel bioactive products as well as aspirin-triggered forms of protectins (AT-PD1… CONTINUE READING

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