Functional Magnetic Resonance Imaging Reveals Different Neural Substrates for the Effects of Orexin-1 and Orexin-2 Receptor Antagonists

@inproceedings{Gozzi2011FunctionalMR,
  title={Functional Magnetic Resonance Imaging Reveals Different Neural Substrates for the Effects of Orexin-1 and Orexin-2 Receptor Antagonists},
  author={Alessandro Gozzi and Giuliano Turrini and Laura Piccoli and Mario Massagrande and David Amantini and Marinella Antolini and Prisca Martinelli and Nicola Cesari and Dino Montanari and Michela A. Tessari and Mauro A Corsi and Angelo Bifone},
  booktitle={PloS one},
  year={2011}
}
Orexins are neuro-modulatory peptides involved in the control of diverse physiological functions through interaction with two receptors, orexin-1 (OX1R) and orexin-2 (OX2R). Recent evidence in pre-clinical models points toward a putative dichotomic role of the two receptors, with OX2R predominantly involved in the regulation of the sleep/wake cycle and arousal, and the OX1R being more specifically involved in reward processing and motivated behaviour. However, the specific neural substrates… CONTINUE READING
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