Functional MRI of somatosensory activation in rat: effect of hypercapnic up-regulation on perfusion- and BOLD-imaging.

@article{Bock1998FunctionalMO,
  title={Functional MRI of somatosensory activation in rat: effect of hypercapnic up-regulation on perfusion- and BOLD-imaging.},
  author={Christoph Bock and Bernd Schmitz and Christian M. Kerskens and Michael Gyngell and K. A. Hossmann and Mathias Hoehn-berlage},
  journal={Magnetic resonance in medicine},
  year={1998},
  volume={39 3},
  pages={457-61}
}
Functional activation of somatosensory cortex was studied in alpha-chloralose anesthetized rats by functional magnetic resonance imaging (fMRI), using both perfusion-weighted and T2*-weighted (blood oxygenation level dependent, BOLD) imaging. The sensitivity of functional activation was altered by ventilating animals for 3 minutes with 6% CO2. Before hypercapnic conditioning, electrical stimulation of the left forepaw at a frequency of 3 Hz led to an increase of signal intensity (relative to… CONTINUE READING

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