Functional MRI of calcium-dependent synaptic activity: cross correlation with CBF and BOLD measurements.

  title={Functional MRI of calcium-dependent synaptic activity: cross correlation with CBF and BOLD measurements.},
  author={Timothy Q. Duong and Afonso C. Silva and S P Lee and Shinseog Kim},
  journal={Magnetic resonance in medicine},
  volume={43 3},
Spatial specificities of the calcium-dependent synaptic activity, hemodynamic-based blood oxygenation level-dependent (BOLD) and cerebral blood flow (CBF) fMRI were quantitatively compared in the same animals. Calcium-dependent synaptic activity was imaged by exploiting the manganese ion (Mn++) as a calcium analog and an MRI contrast agent at 9.4 T. Following forepaw stimulation in alpha-chloralose anesthetized rat, water T1 of the contralateral forepaw somatosensory cortex (SI) was focally and… CONTINUE READING
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