Functional MR imaging correlates of neuropsychological impairment in primary-progressive multiple sclerosis.

BACKGROUND AND PURPOSE Cognitive deficits affect <or=30% of patients with PPMS. We investigated the functional correlates of cognitive network dysfunction in patients with PPMS and their correlation with the extent of structural MR imaging damage. MATERIALS AND METHODS From 16 right-handed patients with PPMS and 17 matched controls, structural and fMRIs… (More)