Functional Loss of Two Ceramide Synthases Elicits Autophagy-Dependent Lifespan Extension in C. elegans

@inproceedings{Mosbech2013FunctionalLO,
  title={Functional Loss of Two Ceramide Synthases Elicits Autophagy-Dependent Lifespan Extension in C. elegans},
  author={Mai-Britt Mosbech and Rikke Kruse and Eva Bang Harvald and Anne S B Olsen and Sandra Fernandez Gallego and Hans Kristian Hannibal-Bach and Christer S Ejsing and Nils J F{\ae}rgeman},
  booktitle={PloS one},
  year={2013}
}
Ceramide and its metabolites constitute a diverse group of lipids, which play important roles as structural entities of biological membranes as well as regulators of cellular growth, differentiation, and development. The C. elegans genome comprises three ceramide synthase genes; hyl-1, hyl-2, and lagr-1. HYL-1 function is required for synthesis of ceramides and sphingolipids containing very long acyl-chains (≥C24), while HYL-2 is required for synthesis of ceramides and sphingolipids containing… CONTINUE READING

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