Functional Long Non-coding RNAs Evolve from Junk Transcripts

@article{Palazzo2020FunctionalLN,
  title={Functional Long Non-coding RNAs Evolve from Junk Transcripts},
  author={Alexander F. Palazzo and Eugene V. Koonin},
  journal={Cell},
  year={2020},
  volume={183},
  pages={1151-1161}
}
Transcriptome studies reveal pervasive transcription of complex genomes, such as those of mammals. Despite popular arguments for functionality of most, if not all, of these transcripts, genome-wide analysis of selective constraints indicates that most of the produced RNA are junk. However, junk is not garbage. On the contrary, junk transcripts provide the raw material for the evolution of diverse long non-coding (lnc) RNAs by non-adaptive mechanisms, such as constructive neutral evolution. The… Expand
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