Functional LCAT is not required for macrophage cholesterol efflux to human serum.


OBJECTIVES To evaluate the capacity of serum from carriers of LCAT gene mutations to promote cell cholesterol efflux through the ABCA1, ABCG1, and SR-BI pathways. METHODS Serum was obtained from 41 carriers of mutant LCAT alleles (14 carriers of two mutant LCAT alleles and 27 heterozygotes) and 10 non-carrier relatives (controls). The capacity of serum to… (More)
DOI: 10.1016/j.atherosclerosis.2008.08.038


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