Functional Investigation of a GRIN2A Variant Associated with Rolandic Epilepsy

@article{Xu2017FunctionalIO,
  title={Functional Investigation of a GRIN2A Variant Associated with Rolandic Epilepsy},
  author={Xing-xing Xu and Xiao-rong Liu and Cui-Ying Fan and Jin-Xing Lai and Yi-wu Shi and Wei Yang and Tao Su and Jun-Yu Xu and Jianhong Luo and Weiping Liao},
  journal={Neuroscience Bulletin},
  year={2017},
  volume={34},
  pages={237-246}
}
N-methyl-D-aspartate receptors (NMDARs), a subtype of glutamate-gated ion channels, play a central role in epileptogenesis. Recent studies have identified an increasing number of GRIN2A (a gene encoding the NMDAR GluN2A subunit) mutations in patients with epilepsy. Phenotypes of GRIN2A mutations include epilepsy-aphasia disorders and other epileptic… CONTINUE READING