Functional Interplay between Type I and II Interferons Is Essential to Limit Influenza A Virus-Induced Tissue Inflammation

@inproceedings{Stifter2016FunctionalIB,
  title={Functional Interplay between Type I and II Interferons Is Essential to Limit Influenza A Virus-Induced Tissue Inflammation},
  author={Sebastian A. Stifter and Nayan Bhattacharyya and Roman Pillay and Manuela Fl{\'o}rido and James A Triccas and Warwick John Britton and Carl G Feng and Paul G. Thomas},
  booktitle={PLoS pathogens},
  year={2016}
}
Host control of influenza A virus (IAV) is associated with exuberant pulmonary inflammation characterized by the influx of myeloid cells and production of proinflammatory cytokines including interferons (IFNs). It is unclear, however, how the immune system clears the virus without causing lethal immunopathology. Here, we demonstrate that in addition to its known anti-viral activity, STAT1 signaling coordinates host inflammation during IAV infection in mice. This regulatory mechanism is… CONTINUE READING
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