Functional Inactivation of a Fraction of Excitatory Synapses in Mice Deficient for the Active Zone Protein Bassoon

  title={Functional Inactivation of a Fraction of Excitatory Synapses in Mice Deficient for the Active Zone Protein Bassoon},
  author={Wilko Detlef Altrock and Susanne tom Dieck and Maxim Sokolov and Alexander C. Meyer and Albrecht Sigler and Cord Brakebusch and Reinhard F{\"a}ssler and K. -D. Richter and Tobias Maria Boeckers and Heidrun Potschka and Claudia Brandt and Wolfgang L{\"o}scher and D{\"o}rte Grimberg and Thomas Dresbach and Anne Hempelmann and Hadir Hassan and Detlef Balschun and Julietta U. Frey and Johann Helmut Brandst{\"a}tter and Craig C. Garner and Christian Rosenmund and Eckart D. Gundelfinger},
Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of synaptic vesicle docking and fusion. Our data show that the loss of Bassoon causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers but are… CONTINUE READING
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