Functional Implications of the CLOCK 3111T/C Single-Nucleotide Polymorphism

  title={Functional Implications of the CLOCK 3111T/C Single-Nucleotide Polymorphism},
  author={Angela R Ozburn and Kush Purohit and Puja K. Parekh and Gabrielle N. Kaplan and Edgardo Falc{\'o}n and Shibani Mukherjee and Hannah M Cates and Colleen A McClung},
  journal={Frontiers in psychiatry},
Circadian rhythm disruptions are prominently associated with bipolar disorder (BD). Circadian rhythms are regulated by the molecular clock, a family of proteins that function together in a transcriptional-translational feedback loop. The CLOCK protein is a key transcription factor of this feedback loop, and previous studies have found that manipulations of the Clock gene are sufficient to produce manic-like behavior in mice (1). The CLOCK 3111T/C single-nucleotide polymorphism (SNP; rs1801260… CONTINUE READING
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