Functional Implications of Novel Human Acid Sphingomyelinase Splice Variants

@inproceedings{Rhein2012FunctionalIO,
  title={Functional Implications of Novel Human Acid Sphingomyelinase Splice Variants},
  author={Cosima Rhein and Philipp Tripal and Angela Seebahn and Alice Konrad and Marcel Kramer and Christine M Nagel and Jonas Kemper and Jens Bode and Christiane M{\"u}hle and Erich Gulbins and M Reichel and Cord-Michael Becker and Johannes Kornhuber},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Acid sphingomyelinase (ASM) hydrolyses sphingomyelin and generates the lipid messenger ceramide, which mediates a variety of stress-related cellular processes. The pathological effects of dysregulated ASM activity are evident in several human diseases and indicate an important functional role for ASM regulation. We investigated alternative splicing as a possible mechanism for regulating cellular ASM activity. METHODOLOGY/PRINCIPAL FINDINGS We identified three novel ASM splice… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 52 REFERENCES

Acid sphingomyelinase in macrophage biology

Jean-Philip Truman, Mohammed M. Al Gadban, Kent J. Smith, Samar M. Hammad
  • Cellular and Molecular Life Sciences
  • 2011
VIEW 1 EXCERPT

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