Functional Immune Cell Differences Associated With Low Vaccine Responses in Infants.

@article{Pichichero2016FunctionalIC,
  title={Functional Immune Cell Differences Associated With Low Vaccine Responses in Infants.},
  author={Michael I. Pichichero and Janet Gallingani Casey and Anthony Almudevar and S Khadeer Basha and Naveen Surendran and Ravinder Kaur and Matthew R. J. Morris and Alexandra M. Livingstone and Tim R. Mosmann},
  journal={The Journal of infectious diseases},
  year={2016},
  volume={213 12},
  pages={
          2014-9
        }
}
BACKGROUND We sought to understand why some children respond poorly to vaccinations in the first year of life. METHODS A total of 499 children (6-36 months old) provided serum and peripheral blood mononuclear cell samples after their primary and booster vaccination. Vaccine antigen-specific antibody levels were analyzed with enzyme-linked immunosorbent assay, and frequency of memory B cells, functional T-cell responses, and antigen-presenting cell responses were assessed in peripheral blood… CONTINUE READING
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