Functional Heterogeneity of Breast Fibroblasts Is Defined by a Prostaglandin Secretory Phenotype that Promotes Expansion of Cancer-Stem Like Cells

@inproceedings{Rudnick2011FunctionalHO,
  title={Functional Heterogeneity of Breast Fibroblasts Is Defined by a Prostaglandin Secretory Phenotype that Promotes Expansion of Cancer-Stem Like Cells},
  author={Jenny A. Rudnick and Lisa M. Arendt and Ina Klebba and John W. Hinds and Venkateswaran K. Iyer and Piyush B. Gupta and S. P. L'Honoré Naber and Charlotte Kuperwasser},
  booktitle={PloS one},
  year={2011}
}
Fibroblasts are important in orchestrating various functions necessary for maintaining normal tissue homeostasis as well as promoting malignant tumor growth. Significant evidence indicates that fibroblasts are functionally heterogeneous with respect to their ability to promote tumor growth, but markers that can be used to distinguish growth promoting from growth suppressing fibroblasts remain ill-defined. Here we show that human breast fibroblasts are functionally heterogeneous with respect to… CONTINUE READING

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Stromal biomarkers in breast cancer development and progression

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