Functional Genomics Deoxycytidylate Deaminase Gene Resequencing and Gemcitabine Pharmacogenomics : Cytidine Deaminase and Updated

@inproceedings{Gilbert2006FunctionalGD,
  title={Functional Genomics Deoxycytidylate Deaminase Gene Resequencing and Gemcitabine Pharmacogenomics : Cytidine Deaminase and Updated},
  author={Judith A. Gilbert and Oreste Ezequel Salavaggione and Yuan Ji and Linda L. Pelleymounter and Bruce W. Eckloff and Eric D. Wieben and MatthewM. Ames and RichardM. Weinshilboum},
  year={2006}
}
Purpose: Gemcitabine is a nucleoside analogue with activity against solid tumors. Gemcitabine metabolic inactivation is catalyzed by cytidine deaminase (CDA) or, after phosphorylation, by deoxycytidylate deaminase (DCTD).We set out to study the pharmacogenomics of CDA and DCTD. Experimental Design:The genes encodingCDA andDCTDwere resequencedusingDNAfrom 60 African American and 60 Caucasian American subjects. Expression constructs were created for nonsynonymous coding single nucleotide… CONTINUE READING