Functional Genomic Analysis Identifies Indoxyl Sulfate as a Major, Poorly Dialyzable Uremic Toxin in End-Stage Renal Disease

@inproceedings{Jhawar2015FunctionalGA,
  title={Functional Genomic Analysis Identifies Indoxyl Sulfate as a Major, Poorly Dialyzable Uremic Toxin in End-Stage Renal Disease},
  author={Sachin Jhawar and Prabhjot Singh and Daniel T Torres and Francisco Ram{\'i}rez-Valle and Hania S. Kassem and Trina Banerjee and Igor Dolgalev and Adriana Heguy and Jiri Zavadil and Jerome Lowenstein},
  booktitle={PloS one},
  year={2015}
}
BACKGROUND Chronic renal failure is characterized by progressive renal scarring and accelerated arteriosclerotic cardiovascular disease despite what is considered to be adequate hemodialysis or peritoneal dialysis. In rodents with reduced renal mass, renal scarring has been attributed to poorly filtered, small protein-bound molecules. The best studied of… CONTINUE READING