Functional Genome Screening to Elucidate the Colistin Resistance Mechanism

@article{Kumar2016FunctionalGS,
  title={Functional Genome Screening to Elucidate the Colistin Resistance Mechanism},
  author={Mohit Kumar and Ashutosh Gupta and Rajesh Kumar Sahoo and Jayanti Jena and Nagen Kumar Debata and Enketeswara Subudhi},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
Antibiogram profile of 1590 clinical bacterial isolates based on thirteen different antimicrobial compounds showed that 1.6% of the bacterial isolates are multidrug resistant. Distribution pattern based on 16S rRNA sequence analysis showed that Pseudomonas aeruginosa constituted the largest group (83.6%) followed by Burkholderia pseudomallei sp. A191 (5.17%), Staphylococcus sp. A261 (3.45%). Among the various antibiotics used, colistin appeared to be the most effective against the Gram negative… 
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