Functional Genetic Variation in Dopamine Signaling Moderates Prefrontal Cortical Activity During Risky Decision Making

@article{Kohno2016FunctionalGV,
  title={Functional Genetic Variation in Dopamine Signaling Moderates Prefrontal Cortical Activity During Risky Decision Making},
  author={Milky Kohno and Erika L Nurmi and Christopher P Laughlin and Angelica M. Morales and Emma H Gail and Gerhard Hellemann and Edythe D. London},
  journal={Neuropsychopharmacology},
  year={2016},
  volume={41},
  pages={695-703}
}
Brain imaging has revealed links between prefrontal activity during risky decision-making and striatal dopamine receptors. Specifically, striatal dopamine D2-like receptor availability is correlated with risk-taking behavior and sensitivity of prefrontal activation to risk in the Balloon Analogue Risk Task (BART). The extent to which these associations, involving a single neurochemical measure, reflect more general effects of dopaminergic functioning on risky decision making, however, is… CONTINUE READING