Functional GATA-3 Binding Sites within Murine CD 8 c Upstream Regulatory Sequences

@inproceedings{Dborah2003FunctionalGB,
  title={Functional GATA-3 Binding Sites within Murine CD 8 c Upstream Regulatory Sequences},
  author={D{\'e}borah and Bernard Landry and James Douglas Engel and Ranjan Sen},
  year={2003}
}
Genes encoding the accessory molecules CD8 and CD4 are activated early in thymocyte development, generating CD4 + 8 + double positive intermediates, which give rise to two functionally distinct mature T cell subsets that express either CD4 or CD8. The mechanisms that govern the activation or suppression of the CD8 gene are likely to be central to the T cell development program. To identify the key regulatory factors, we have initiated an analysis of the transcriptional regulation of the routine… CONTINUE READING