Functional GABAA receptor heterogeneity of acutely dissociated hippocampal CA1 pyramidal cells.

@article{Tietz1999FunctionalGR,
  title={Functional GABAA receptor heterogeneity of acutely dissociated hippocampal CA1 pyramidal cells.},
  author={Elizabeth I. Tietz and Jaideep Kapur and Robert L Macdonald},
  journal={Journal of neurophysiology},
  year={1999},
  volume={81 4},
  pages={1575-86}
}
CA1 pyramidal cells were voltage clamped, and GABA was applied to individual cells with a modified U-tube, rapid drug application system. With Vh = -50 mV, inward currents elicited by 10 microM GABA were inhibited by GABAA receptor (GABAR) antagonists and were baclofen insensitive, suggesting that GABA actions on isolated CA1 pyramidal cells were GABAR mediated. GABA concentration-response curves averaged from all cells were fitted best with a two-site equation, indicating the presence of at… CONTINUE READING

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Theg2 subunit of the GABA receptor is concentrated in synaptic junctions containing thea1 andb2/3 subunits in hippocampus, cerebellum and globus pallidus.Neuropharmacology35: 1425–1444

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  • 1996
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