Functional Expression and Characterization of G-protein-gated Inwardly Rectifying K+ Channels Containing GIRK3

@article{Jelacic1999FunctionalEA,
  title={Functional Expression and Characterization of G-protein-gated Inwardly Rectifying K+ Channels Containing GIRK3},
  author={T. M. Jelacic and Stephen Michael Sims and David E Clapham},
  journal={The Journal of Membrane Biology},
  year={1999},
  volume={169},
  pages={123-129}
}
The G-protein-gated inwardly rectifying K +(GIRK) family of ion channels form functional Gβγ-sensitive channels as heteromultimers of GIRK1 and either the GIRK2 or GIRK4 subunits. However, the homologous mouse brain GIRK3 clone failed to express in the earliest reported functional experiments in Xenopus oocytes. We recloned the GIRK3 subunit from mouse brain and found that the new clone differed significantly from that originally reported. The functional aspects of GIRK3 were reinvestigated by… CONTINUE READING

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