Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells

@article{Chambers2003FunctionalEC,
  title={Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells},
  author={I. Chambers and D. Colby and M. Robertson and J. Nichols and Sonia A Lee and S. Tweedie and Andrew Smith},
  journal={Cell},
  year={2003},
  volume={113},
  pages={643-655}
}
Embryonic stem (ES) cells undergo extended proliferation while remaining poised for multilineage differentiation. A unique network of transcription factors may characterize self-renewal and simultaneously suppress differentiation. We applied expression cloning in mouse ES cells to isolate a self-renewal determinant. Nanog is a divergent homeodomain protein that directs propagation of undifferentiated ES cells. Nanog mRNA is present in pluripotent mouse and human cell lines, and absent from… Expand
A Heterogeneous Expression Pattern for Nanog in Embryonic Stem Cells
The molecular basis of pluripotency in mouse embryonic stem cells.
NANOG maintains self‐renewal of primate ES cells in the absence of a feeder layer
Transcriptional heterogeneity in mouse embryonic stem cells.
Self-renewal of teratocarcinoma and embryonic stem cells
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 88 REFERENCES
Paracrine induction of stem cell renewal by LIF-deficient cells: a new ES cell regulatory pathway.
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3.
Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture
Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation
Generation of purified neural precursors from embryonic stem cells by lineage selection
Molecular mechanism to maintain stem cell renewal of ES cells.
  • H. Niwa
  • Biology, Medicine
  • Cell structure and function
  • 2001
Signaling Mechanisms Regulating Self-Renewal and Differentiation of Pluripotent Embryonic Stem Cells
...
1
2
3
4
5
...