Functional Enhancers at the Gene-Poor 8q24 Cancer-Linked Locus

@inproceedings{Jia2009FunctionalEA,
  title={Functional Enhancers at the Gene-Poor 8q24 Cancer-Linked Locus},
  author={Li Jia and Gilad Landan and Mark M Pomerantz and Rami Jaschek and Paula Herman and David Reich and Chunli Yan and O. U. Khalid and Phil Kantoff and William K Oh and J. Robert Manak and Benjamin P. Berman and Brian E. Henderson and Baruch Frenkel and Christopher A. Haiman and Matthew A Freedman and Amos Tanay and Gerhard A. Coetzee},
  booktitle={PLoS genetics},
  year={2009}
}
Multiple discrete regions at 8q24 were recently shown to contain alleles that predispose to many cancers including prostate, breast, and colon. These regions are far from any annotated gene and their biological activities have been unknown. Here we profiled a 5-megabase chromatin segment encompassing all the risk regions for RNA expression, histone modifications, and locations occupied by RNA polymerase II and androgen receptor (AR). This led to the identification of several transcriptional… CONTINUE READING

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