Functional Effects of Toll-Like Receptor (TLR)3, 7, 9, RIG-I and MDA-5 Stimulation in Nasal Epithelial Cells

@inproceedings{Tengroth2014FunctionalEO,
  title={Functional Effects of Toll-Like Receptor (TLR)3, 7, 9, RIG-I and MDA-5 Stimulation in Nasal Epithelial Cells},
  author={Lotta Tengroth and Camilla Rydberg Millrud and Anne M{\aa}nsson Kvarnhammar and Susanna Kumlien Geor{\'e}n and Lydia Abdul Latif and Lars Olaf Cardell},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND The human nasal epithelium is an important physical barrier, and a part of the innate immune defense that protect against pathogens. The epithelial cells recognize microbial components by pattern-recognition receptors (PRRs), and thereby trigger an immune response. Even though TLR3, TLR7, TLR9, RIG-I and MDA-5 are all known to respond to viral stimulation, their potential role in chronic airway inflammation triggered by local cytokine release remains to be established. METHODS mRNA… CONTINUE READING

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