Functional Effects of Schizophrenia-Linked Genetic Variants on Intrinsic Single-Neuron Excitability: A Modeling Study.

@article{MkiMarttunen2016FunctionalEO,
  title={Functional Effects of Schizophrenia-Linked Genetic Variants on Intrinsic Single-Neuron Excitability: A Modeling Study.},
  author={T. M{\"a}ki-Marttunen and G. Halnes and A. Devor and A. Witoelar and F. Bettella and S. Djurovic and Yunpeng Wang and G. Einevoll and O. Andreassen and A. Dale},
  journal={Biological psychiatry. Cognitive neuroscience and neuroimaging},
  year={2016},
  volume={1 1},
  pages={
          49-59
        }
}
BACKGROUND Recent genome-wide association studies have identified a large number of genetic risk factors for schizophrenia (SCZ) featuring ion channels and calcium transporters. For some of these risk factors, independent prior investigations have examined the effects of genetic alterations on the cellular electrical excitability and calcium homeostasis. In the present proof-of-concept study, we harnessed these experimental results for modeling of computational properties on layer V cortical… Expand
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Variants of voltage-gated Na+ channel or hyperpolarization-activated cation channel-encoding genes cause qualitatively similar effects on layer V pyramidal cell and sinoatrial node cell excitability, which may help explain some of the cardiac comorbidity in schizophrenia, and may facilitate generation of effective antipsychotic medications without cardiac side-effects such as arrhythmia. Expand
Title Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling Permalink
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