Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution

@article{Kim2015FunctionalDO,
  title={Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution},
  author={Namhee Kim and Chungoo Park and Yongsu Jeong and Mi-Ryoung Song},
  journal={PLoS Genetics},
  year={2015},
  volume={11}
}
Functional diversification of motor neurons has occurred in order to selectively control the movements of different body parts including head, trunk and limbs. Here we report that transcription of Isl1, a major gene necessary for motor neuron identity, is controlled by two enhancers, CREST1 (E1) and CREST2 (E2) that allow selective gene expression of Isl1 in motor neurons. Introduction of GFP reporters into the chick neural tube revealed that E1 is active in hindbrain motor neurons and spinal… 

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