Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution
@article{Kim2015FunctionalDO, title={Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution}, author={Namhee Kim and Chungoo Park and Yongsu Jeong and Mi-Ryoung Song}, journal={PLoS Genetics}, year={2015}, volume={11} }
Functional diversification of motor neurons has occurred in order to selectively control the movements of different body parts including head, trunk and limbs. Here we report that transcription of Isl1, a major gene necessary for motor neuron identity, is controlled by two enhancers, CREST1 (E1) and CREST2 (E2) that allow selective gene expression of Isl1 in motor neurons. Introduction of GFP reporters into the chick neural tube revealed that E1 is active in hindbrain motor neurons and spinal…
16 Citations
ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons
- BiologyScientific reports
- 2016
It is demonstrated that the ISL1 controls postmitotic cranial branchiomotor (BM) neurons including the positioning of the cell bodies and peripheral axon pathfinding and combinations of ISL 1 and LHX factors establish cell-type specificity and functional diversity in terms of motor neuron identities and/or axon development.
Transcriptional Regulation in Spinal Cord Motor Neuron Specification and Motor Neuron Subtype Development
- Biology
- 2016
Motor neuron progenitor cells rapidly induce high expression of the transcription factors Isl1 and Lhx3 as well as LMO4 as they exit the cell cycle and differentiate. Isl1 and Lhx3 form the Isl1-Lhx3…
The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development
- BiologyFront. Mol. Neurosci.
- 2017
It is demonstrated that the Onecut transcription factors, namely Hepatocyte Nuclear Factor-6 (HNF-6) (or OC-1), OC-2 and OC-3, regulate the diversification and the distribution of spinal dorsal interneuron (dINs) during embryonic development.
The Isl1-Lhx3 Complex Promotes Motor Neuron Specification by Activating Transcriptional Pathways that Enhance Its Own Expression and Formation
- BiologyeNeuro
- 2017
These findings support a model in which the Isl1-Lhx3 complex amplifies its own expression through a potent autoregulatory feedback loop and simultaneously enhances the transcription of Lmo4 in embryonic MNs of chick and mouse.
Adult islet1 Expression Outlines Ventralized Derivatives Along Zebrafish Neuraxis
- BiologyFront. Neuroanat.
- 2019
It is hypothesized that the larval expression of sonic hedgehog (shh) might causally underlie much of adult islet1 expression because it explains findings beyond ventrally located systems, for example regarding shh expression in the zona limitans intrathalamica and correlated is let1-GFP expression inThe thalamus.
An ensemble of regulatory elements controls Runx3 spatiotemporal expression in subsets of dorsal root ganglia proprioceptive neurons.
- BiologyGenes & development
- 2016
The analysis reveals that an intricate combinatorial interplay among the three REs governs Runx3 expression in distinct subtypes of TrkC neurons while concomitantly extinguishing its expression in non-TrKC neurons.
Gata6 restricts Isl1 to the posterior of nascent hindlimb buds through Isl1 cis-regulatory modules.
- BiologyDevelopmental biology
- 2018
CBP and p300 coactivators contribute to the maintenance of Isl1 expression by the Onecut transcription factors in embryonic spinal motor neurons
- BiologyMolecular and Cellular Neuroscience
- 2019
Onecut Regulates Core Components of the Molecular Machinery for Neurotransmission in Photoreceptor Differentiation
- BiologyFrontiers in Cell and Developmental Biology
- 2021
Transgenic perturbation of the Ciona robusta Oc protein is used to show its requirement for ciliary PRC differentiation and transcriptome profiling between the trans-activation and trans-repression Oc phenotypes identified differentially expressed genes that are enriched in exocytosis, calcium homeostasis, and neurotransmission.
References
SHOWING 1-10 OF 88 REFERENCES
Comparative functional genomics revealed conservation and diversification of three enhancers of the isl1 gene for motor and sensory neuron-specific expression.
- BiologyDevelopmental biology
- 2005
Requirement for LIM Homeobox Gene Isl1 in Motor Neuron Generation Reveals a Motor Neuron– Dependent Step in Interneuron Differentiation
- BiologyCell
- 1996
Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b.
- BiologyDevelopment
- 2000
Genetic evidence is provided that the paired-like homeodomain protein Phox2b is required for the formation of all branchial and visceral, but not somatic, motor neurons in the hindbrain, which exemplifies a novel control point in the generation of CNS neurons.
Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification
- BiologyDevelopment
- 2012
It is demonstrated that the transcriptional activators of the Onecut family critically regulate MN subtype diversification during spinal cord development and Sip1 (Zeb2) is identified as a novel developmental regulator of visceral MN differentiation.
A Postmitotic Role for Isl-Class LIM Homeodomain Proteins in the Assignment of Visceral Spinal Motor Neuron Identity
- BiologyNeuron
- 2004
Global Control of Motor Neuron Topography Mediated by the Repressive Actions of a Single Hox Gene
- Biology, PsychologyNeuron
- 2010
EphA4 constitutes a population-specific guidance cue for motor neurons.
- BiologyDevelopmental biology
- 2002
It is shown that ectopic expression of EphA4 receptor tyrosine kinase alters the trajectories of a specific population of motor axons in the avian hindlimb, and suggests that EPhA4 in motor neurons acts as a population-specific guidance cue to control the dorsal trajectory of their axonsIn the hind Limb.
Transcriptional codes and the control of neuronal identity.
- BiologyAnnual review of neuroscience
- 2002
The actions of transcription factors within motor neuron progenitors, which initiate a cascade of transcriptional interactions that lead to motor neuron specification, are described and the downstream targets of the LIM code are discussed, especially in the context of subtype-specific motor axon pathfinding.
T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration
- BiologyDevelopment
- 2006
This study suggests that Tbx20 programs a variety of hindbrain motor neurons for migration, independent of directionality, and in facial neurons is a positive regulator of the non-canonical Wnt signaling pathway.