Functional Divergence of Diterpene Syntheses in the Medicinal Plant Salvia miltiorrhiza.

Abstract

The medicinal plant Salvia miltiorrhiza produces various tanshinone diterpenoids that have pharmacological activities such as vasorelaxation against ischemia reperfusion injury and antiarrhythmic effects. Their biosynthesis is initiated from the general diterpenoid precursor (E,E,E)-geranylgeranyl diphosphate by sequential reactions catalyzed by copalyl… (More)
DOI: 10.1104/pp.15.00695

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