Functional Divergence in Protein (Family) Sequence Evolution

  title={Functional Divergence in Protein (Family) Sequence Evolution},
  author={Xun Gu},
As widely used today to infer ‘function’, the homology search is based on the neutral theory that sites of greatest functional significance are under the strongest selective constraints as well as lowest evolutionary rates, and vice versa. Therefore, site-specific rate changes (or altered selective constraints) are related to functional divergence during protein (family) evolution. In this paper, we review our recent work about this issue. We show a great deal of functional information can be… CONTINUE READING

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Statistical methods for testing functional divergence after gene

  • X. Gu
  • duplication. Mol. Biol. Evol
  • 1999
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