Functional Discovery via a Compendium of Expression Profiles

@article{Hughes2000FunctionalDV,
  title={Functional Discovery via a Compendium of Expression Profiles},
  author={Timothy R. Hughes and Matthew J. Marton and Allan R. Jones and Christopher J Roberts and Roland Stoughton and Christopher D. Armour and Holly A. Bennett and Ernest M. Coffey and Hongyue Dai and Yudong D. He and Matthew J. Kidd and Amy M King and Michael R. Meyer and David A. Slade and Pek Y. Lum and Sergey B. Stepaniants and D. DeWayne Shoemaker and Daniel Gachotte and Kalpana Chakraburtty and Julian Simon and Martin Bard and Stephen H. Friend},
  journal={Cell},
  year={2000},
  volume={102},
  pages={109-126}
}
Ascertaining the impact of uncharacterized perturbations on the cell is a fundamental problem in biology. Here, we describe how a single assay can be used to monitor hundreds of different cellular functions simultaneously. We constructed a reference database or "compendium" of expression profiles corresponding to 300 diverse mutations and chemical treatments in S. cerevisiae, and we show that the cellular pathways affected can be determined by pattern matching, even among very subtle profiles… CONTINUE READING
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