Functional Discovery via a Compendium of Expression Profiles

  title={Functional Discovery via a Compendium of Expression Profiles},
  author={Timothy R. Hughes and Matthew J. Marton and Allan R. Jones and Christopher J Roberts and Roland Stoughton and Christopher D. Armour and Holly A. Bennett and Ernest M. Coffey and Hongyue Dai and Yudong D. He and Matthew J. Kidd and Amy M King and Michael R. Meyer and David A. Slade and Pek Y. Lum and Sergey B. Stepaniants and D. DeWayne Shoemaker and Daniel Gachotte and Kalpana Chakraburtty and Julian Simon and Martin Bard and Stephen H. Friend},
Ascertaining the impact of uncharacterized perturbations on the cell is a fundamental problem in biology. Here, we describe how a single assay can be used to monitor hundreds of different cellular functions simultaneously. We constructed a reference database or "compendium" of expression profiles corresponding to 300 diverse mutations and chemical treatments in S. cerevisiae, and we show that the cellular pathways affected can be determined by pattern matching, even among very subtle profiles… CONTINUE READING
Highly Influential
This paper has highly influenced 143 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 1,363 extracted citations


Publications referenced by this paper.
Showing 1-10 of 71 references

Cells were grown to nearly efficient copper detoxification , mitochondrial function , and iron meidentical densities in midlog phase , washed 3 times with TE , and tabolism

  • M. B. Eisen, P. T. Spellman, P. O. Brown, D. Botstein
  • Mol Gen . Genet .
  • 1998
Highly Influential
6 Excerpts

Signaling and circuitry protein complexes using mass spectrometry

  • C. Boone, S. H. Friend
  • Nat . Biotechnol .
  • 2000

A a yeast gene ( VMA 8 ) encoding the subunit D of the vacuolar H ( 1 )novel human gene , encoding a potential membrane protein conATPase

  • V. H. Nguyen, S. L. Ingram, M. Kassiou, M. J. Christie
  • Proc . Natl . Acad . Sci . USA
  • 1999

A combined algorithm for genome - wide preNat

  • M. Pellegrini, M. J. Thompson, T. O. Yeates, D. Eisenberg
  • Genet . Nature
  • 1999

Similar Papers

Loading similar papers…