Functional Differences Between Direct and Indirect Striatal Output Pathways in Huntington's Disease.


There is morphological evidence for differential alterations in striatal medium-sized spiny neurons (MSNs) giving rise to the direct and indirect output pathways in Huntington's disease (HD). MSNs of the indirect pathway appear to be particularly vulnerable and markers for these neurons are lost early in postmortem brains and in genetic mouse models. In… (More)
DOI: 10.3233/JHD-2012-120009


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