Functional DNA methylation in a transcript specific 3'UTR region of TrkB associates with suicide.

@article{Maussion2014FunctionalDM,
  title={Functional DNA methylation in a transcript specific 3'UTR region of TrkB associates with suicide.},
  author={Gilles Maussion and Jennie Ping Yang and Matthew J. Suderman and Alpha B. Diallo and Corina Nagy and Mitchell Arnovitz and Naguib Mechawar and Gustavo Turecki},
  journal={Epigenetics},
  year={2014},
  volume={9 8},
  pages={1061-70}
}
Previous studies indicate that a subgroup of suicide completers has low cortical brain expression levels of TrkB-T1, a TrkB gene transcript that is highly expressed in astrocytes. Epigenetic modifications, including methylation changes in the TrkB promoter, partially explain TrkB-T1 low expression levels in brain tissue from suicide completers. The aim of this study was to investigate whether methylation changes in other regions of the TrkB gene could also contribute to the significant… CONTINUE READING
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