Functional Cutaneous Lymphocyte Antigen Can Be Induced in Essentially All Peripheral Blood T Lymphocytes

@article{Armerding1999FunctionalCL,
  title={Functional Cutaneous Lymphocyte Antigen Can Be Induced in Essentially All Peripheral Blood T Lymphocytes},
  author={Dieter Armerding and Thomas Seth Kupper},
  journal={International Archives of Allergy and Immunology},
  year={1999},
  volume={119},
  pages={212 - 222}
}
  • Dieter Armerding, Thomas Seth Kupper
  • Published in
    International Archives of…
    1999
  • Biology, Medicine
  • The cutaneous lymphocyte–associated antigen (CLA) is a skin–homing receptor expressed on a minority of memory–type peripheral blood T (PBT) lymphocytes. Induction of high–level CLA expression in PBT has previously been difficult to accomplish in vitro. Here we report that constitutive CLA expression could be readily induced in virtually all PBT by various polyclonal activators. There was no requirement for accessory cells or addition of other mediators except for IL–2 for maintaining cell… CONTINUE READING

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