Functional CpG Methylation System in a Social Insect

  title={Functional CpG Methylation System in a Social Insect},
  author={Y. Wang and M. Jord{\`a} and P. Jones and R. Maleszka and X. Ling and H. M. Robertson and C. A. Mizzen and M. A. Peinado and G. Robinson},
  pages={645 - 647}
  • Y. Wang, M. Jordà, +6 authors G. Robinson
  • Published 2006
  • Biology, Medicine
  • Science
  • DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogaster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5… CONTINUE READING
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