Functional CpG Methylation System in a Social Insect
@article{Wang2006FunctionalCM, title={Functional CpG Methylation System in a Social Insect}, author={Y. Wang and M. Jord{\`a} and P. Jones and R. Maleszka and X. Ling and H. M. Robertson and C. A. Mizzen and M. A. Peinado and G. Robinson}, journal={Science}, year={2006}, volume={314}, pages={645 - 647} }
DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogaster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5… CONTINUE READING
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References
SHOWING 1-10 OF 18 REFERENCES
Genomic DNA methylation: the mark and its mediators.
- Biology, Medicine
- Trends in biochemical sciences
- 2006
- 2,243
- PDF
Methylation of genomes and genes at the invertebrate-vertebrate boundary.
- Biology, Medicine
- Molecular and cellular biology
- 1997
- 239
- PDF
Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
- Biology, Medicine
- Nature Genetics
- 1999
- 827
The Drosophila MBD2/3 protein mediates interactions between the MI-2 chromatin complex and CpT/A-methylated DNA
- Biology, Medicine
- Development
- 2004
- 60
- PDF
Methylation and expression of amplified esterase genes in the aphid Myzus persicae (Sulzer).
- Biology, Medicine
- The Biochemical journal
- 2000
- 78
- PDF
Sin3: a flexible regulator of global gene expression and genome stability
- Biology, Medicine
- Current Genetics
- 2004
- 281