Functional CpG Methylation System in a Social Insect

@article{Wang2006FunctionalCM,
  title={Functional CpG Methylation System in a Social Insect},
  author={Ying Wang and Mireia Jord{\`a} and Peter L Jones and Ryszard Maleszka and Xu Ling and Hugh M. Robertson and Craig A. Mizzen and Miguel A. Peinado and Gene E. Robinson},
  journal={Science},
  year={2006},
  volume={314},
  pages={645 - 647}
}
DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogaster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5… 
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