• DOI:10.1126/SCIENCE.1135213
Corpus ID: 31709665

Functional CpG Methylation System in a Social Insect

@article{Wang2006FunctionalCM,
  title={Functional CpG Methylation System in a Social Insect},
  author={Y. Wang and M. Jord{\`a} and P. Jones and R. Maleszka and X. Ling and H. M. Robertson and C. A. Mizzen and M. A. Peinado and G. Robinson},
  journal={Science},
  year={2006},
  volume={314},
  pages={645 - 647}
}

Y. Wang, M. Jordà, +6 authors G. Robinson

Published 2006

Biology, Medicine

Science

DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogaster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5… CONTINUE READING

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