Functional Coupling of the Amygdala in Depressed Patients Treated with Antidepressant Medication

@article{Chen2008FunctionalCO,
  title={Functional Coupling of the Amygdala in Depressed Patients Treated with Antidepressant Medication},
  author={Chi-Hua Chen and John Suckling and Cinly Ooi and Cynthia H. Y. Fu and S. C. Williams and Nicholas D. Walsh and Martina T Mitterschiffthaler and Emilio Merlo Pich and Ed Bullmore},
  journal={Neuropsychopharmacology},
  year={2008},
  volume={33},
  pages={1909-1918}
}
The amygdala plays a central role in various aspects of affect processing and mood regulation by its rich anatomical connections to other limbic and cortical regions. It is plausible that depressive disorders, and response to antidepressant drugs, may reflect changes in the physiological coupling between the amygdala and other components of affect-related large-scale brain systems. We explored this hypothesis by mapping the functional coupling of right and left amygdalae in functional magnetic… CONTINUE READING
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These results indicate that antidepressant drug effects can be measured in terms of altered coupling between components of cortico - limbic systems and that these effects were most clearly demonstrated by enhanced functional coupling of the left amygdala .
These results indicate that antidepressant drug effects can be measured in terms of altered coupling between components of cortico - limbic systems and that these effects were most clearly demonstrated by enhanced functional coupling of the left amygdala .
Between scanning sessions , the patients received treatment with an antidepressant drug , fluoxetine 20 mg / day .
Between scanning sessions , the patients received treatment with an antidepressant drug , fluoxetine 20 mg / day .
Between scanning sessions , the patients received treatment with an antidepressant drug , fluoxetine 20 mg / day .
Between scanning sessions , the patients received treatment with an antidepressant drug , fluoxetine 20 mg / day .
Between scanning sessions , the patients received treatment with an antidepressant drug , fluoxetine 20 mg / day .
Between scanning sessions , the patients received treatment with an antidepressant drug , fluoxetine 20 mg / day .
These results indicate that antidepressant drug effects can be measured in terms of altered coupling between components of cortico - limbic systems and that these effects were most clearly demonstrated by enhanced functional coupling of the left amygdala .
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