Functional Coupling of Ca2+ Channels to Ryanodine Receptors at Presynaptic Terminals

@article{Narita2000FunctionalCO,
  title={Functional Coupling of Ca2+ Channels to Ryanodine Receptors at Presynaptic Terminals},
  author={Kinya Narita and Tenpei Akita and Junichi Hachisuka and S M Huang and Kentaro Ochi and Kenji Kuba},
  journal={The Journal of General Physiology},
  year={2000},
  volume={115},
  pages={519 - 532}
}
Ca(2+)-induced Ca(2+) release (CICR) enhances a variety of cellular Ca(2+) signaling and functions. How CICR affects impulse-evoked transmitter release is unknown. At frog motor nerve terminals, repetitive Ca(2+) entries slowly prime and subsequently activate the mechanism of CICR via ryanodine receptors and asynchronous exocytosis of transmitters. Further Ca(2+) entry inactivates the CICR mechanism and the absence of Ca(2+) entry for >1 min results in its slow depriming. We now report here… CONTINUE READING

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