Functional Copy-Number Alterations in Cancer

  title={Functional Copy-Number Alterations in Cancer},
  author={Barry S. Taylor and Jordi G Barretina and Nicholas D. Socci and Penelope L Decarolis and Marc Ladanyi and Matthew Meyerson and Samuel Singer and Chris Sander},
  journal={PLoS ONE},
  pages={369 - 376}
Understanding the molecular basis of cancer requires characterization of its genetic defects. DNA microarray technologies can provide detailed raw data about chromosomal aberrations in tumor samples. Computational analysis is needed (1) to deduce from raw array data actual amplification or deletion events for chromosomal fragments and (2) to distinguish causal chromosomal alterations from functionally neutral ones. We present a comprehensive computational approach, RAE, designed to robustly map… CONTINUE READING

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