Functional Conservation of Asxl2, a Murine Homolog for the Drosophila Enhancer of Trithorax and Polycomb Group Gene Asx

@article{Baskind2009FunctionalCO,
  title={Functional Conservation of Asxl2, a Murine Homolog for the Drosophila Enhancer of Trithorax and Polycomb Group Gene Asx},
  author={Heather A. Baskind and Lucy Na and Quanhong Ma and Mayur P. Patel and David L. Geenen and Q. Tian Wang},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={91 - 94}
}
BACKGROUND Polycomb-group (PcG) and trithorax-group (trxG) proteins regulate histone methylation to establish repressive and active chromatin configurations at target loci, respectively. These chromatin configurations are passed on from mother to daughter cells, thereby causing heritable changes in gene expression. The activities of PcG and trxG proteins are regulated by a special class of proteins known as Enhancers of trithorax and Polycomb (ETP). The Drosophila gene Additional sex combs (Asx… CONTINUE READING
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