Functional Consequences of a Novel Variant of PCSK1

  title={Functional Consequences of a Novel Variant of PCSK1},
  author={Lindsay A. Pickett and Michael Yourshaw and Valeria Albornoz and Zijun Chen and R. Sergio Solorzano-Vargas and Stanley F. Nelson and Mart{\'i}n G. Mart{\'i}n and Iris Lindberg},
  booktitle={PloS one},
BACKGROUND Common single nucleotide polymorphisms (SNPs) in proprotein convertase subtilisin/kexin type 1 with modest effects on PC1/3 in vitro have been associated with obesity in five genome-wide association studies and with diabetes in one genome-wide association study. We here present a novel SNP and compare its biosynthesis, secretion and catalytic… CONTINUE READING