Functional Connectivity Mapping in the Animal Model: Principles and Applications of Resting-State fMRI

  title={Functional Connectivity Mapping in the Animal Model: Principles and Applications of Resting-State fMRI},
  author={Martin Gorges and Francesco Roselli and Hans-Peter M{\"u}ller and Albert Christian Ludolph and Volker Rasche and Jan Kassubek},
  journal={Frontiers in Neurology},
“Resting-state” fMRI has substantially contributed to the understanding of human and non-human functional brain organization by the analysis of correlated patterns in spontaneous activity within dedicated brain systems. Spontaneous neural activity is indirectly measured from the blood oxygenation level-dependent signal as acquired by echo planar imaging, when subjects quietly “resting” in the scanner. Animal models including disease or knockout models allow a broad spectrum of experimental… 
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